Version 5.4
Bos taurus Protein: F13A1
Summary
InnateDB Protein IDBP-688461.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F13A1
Protein Name Coagulation factor XIII A chain
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000009559
InnateDB Gene IDBG-636530 (F13A1)
Protein Structure
UniProt Annotation
Function Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Subcellular Localization Cytoplasm. Secreted. Note=Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0046872 metal ion binding
Biological Process
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0018149 peptide cross-linking
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR001102 Transglutaminase, N-terminal
IPR002931 Transglutaminase-like
IPR008958 Transglutaminase, C-terminal
IPR014756 Immunoglobulin E-set
PFAM PF00868
PF01841
PF00927
PRINTS
PIRSF
SMART SM00460
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P12260
PhosphoSite PhosphoSite-
TrEMBL Q27982
UniProt Splice Variant
Entrez Gene 617881
UniGene Bt.19195
RefSeq NP_001161366
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT025350 DAAA02055840 DAAA02055841 DAAA02055842 DAAA02055843 DAAA02055844 DAAA02055845 U13392
GenPept AAB60265 ABF57306

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca