Version 5.4
Bos taurus Protein: KCND1
Summary
InnateDB Protein IDBP-688992.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCND1
Protein Name Potassium voltage-gated channel subfamily D member 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000011882
InnateDB Gene IDBG-637014 (KCND1)
Protein Structure
UniProt Annotation
Function Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005267 potassium channel activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0042995 cell projection
Protein Structure and Domains
PDB ID
InterPro IPR000210 BTB/POZ-like
IPR003091 Potassium channel
IPR003131 Potassium channel tetramerisation-type BTB domain
IPR003968 Potassium channel, voltage dependent, Kv
IPR003971 Potassium channel, voltage dependent, Kv9
IPR003974 Potassium channel, voltage dependent, Kv3
IPR003975 Potassium channel, voltage dependent, Kv4
IPR004054 Potassium channel, voltage dependent, Kv4.1
IPR005821 Ion transport domain
IPR011333 BTB/POZ fold
IPR013099 Two pore domain potassium channel domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR021645 Shal-type voltage-gated potassium channels
IPR024587 Potassium channel, voltage dependent, Kv4, C-terminal
PFAM PF02214
PF00520
PF07885
PF08016
PF11601
PF11879
PRINTS PR00169
PR01491
PR01494
PR01498
PR01497
PR01516
PIRSF
SMART SM00225
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q52PG9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 518384
UniGene Bt.8644
RefSeq NP_001019724
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY989810
GenPept AAX89129

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca