InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: DNMT3A

Summary

InnateDB Protein

IDBP-689202.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNMT3A

Protein Name

DNA (cytosine-5-)-methyltransferase 3 alpha

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000032863

InnateDB Gene

IDBG-637166 (DNMT3A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003886	DNA (cytosine-5-)-methyltransferase activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006306	DNA methylation
GO:0006346	methylation-dependent chromatin silencing
GO:0006349	regulation of gene expression by genetic imprinting
GO:0007283	spermatogenesis
GO:0043045	DNA methylation involved in embryo development
GO:0043046	DNA methylation involved in gamete generation
GO:0044027	hypermethylation of CpG island
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000791	euchromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005720	nuclear heterochromatin
GO:0005737	cytoplasm
GO:0016363	nuclear matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000313 PWWP domain
IPR001525 C-5 cytosine methyltransferase
IPR011011 Zinc finger, FYVE/PHD-type
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00855
PF00145

PRINTS

PR00105

PIRSF

SMART

SM00293

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt