Version 5.4
Bos taurus Protein: RNF20
Summary
InnateDB Protein IDBP-689206.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF20
Protein Name E3 ubiquitin-protein ligase BRE1A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012521
InnateDB Gene IDBG-637202 (RNF20)
Protein Structure
UniProt Annotation
Function Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0042393 histone binding
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006355 regulation of transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007165 signal transduction
GO:0010390 histone monoubiquitination
GO:0016567 protein ubiquitination
GO:0016568 chromatin modification
GO:0016574 histone ubiquitination
GO:0030336 negative regulation of cell migration
GO:0031062 positive regulation of histone methylation
GO:0033523 histone H2B ubiquitination
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0033503 HULC complex
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR015988 STAT transcription factor, coiled coil
PFAM PF13639
PF14634
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2VDP1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 513326
UniGene Bt.10397
RefSeq NP_001075056
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133334
GenPept AAI33335

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca