Bos taurus Gene: RNF20
InnateDB Gene IDBG-637202.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF20
Gene Name E3 ubiquitin-protein ligase BRE1A
Species Bos taurus
Ensembl Gene ENSBTAG00000009516
Encoded Proteins
E3 ubiquitin-protein ligase BRE1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000155827:
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:92911255-92935750
Strand Forward strand
ENSBTAT00000012521 ENSBTAP00000012521
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0042393 histone binding
GO:0046872 metal ion binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0006355 regulation of transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007165 signal transduction
GO:0010390 histone monoubiquitination
GO:0016567 protein ubiquitination
GO:0016568 chromatin modification
GO:0016574 histone ubiquitination
GO:0030336 negative regulation of cell migration
GO:0031062 positive regulation of histone methylation
GO:0033523 histone H2B ubiquitination
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0033503 HULC complex
Homo sapiens
Mus musculus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
UniProt Splice Variant
Entrez Gene
UniGene Bt.10397
RefSeq NM_001081587 XM_005210486 XM_005210487
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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