InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TXN

Summary

InnateDB Protein

IDBP-689716.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TXN

Protein Name

Thioredoxin

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000041860

InnateDB Gene

IDBG-637688 (TXN)

Protein Structure

UniProt Annotation

Function

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=Secreted by a leaderless secretory pathway. Predominantly in the cytoplasm in non irradiated cells. Radiation induces translocation of TRX from the cytoplasm to the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.

Predicted by orthology
Total	63 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0015037	peptide disulfide oxidoreductase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006662	glycerol ether metabolic process
GO:0009314	response to radiation
GO:0033158	regulation of protein import into nucleus, translocation
GO:0043388	positive regulation of DNA binding
GO:0045454	cell redox homeostasis
GO:0046826	negative regulation of protein export from nucleus
GO:0055114	oxidation-reduction process