Version 5.4
Bos taurus Protein: PLA2G4A
Summary
InnateDB Protein IDBP-689816.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLA2G4A
Protein Name Cytosolic phospholipase A2Phospholipase A2Lysophospholipase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017685
InnateDB Gene IDBG-637785 (PLA2G4A)
Protein Structure
UniProt Annotation
Function Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Translocates to membrane vesicles in a calcium-dependent fashion. {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in granulosa cells after stimulation with chorionic gonadotropin (at protein level). {ECO:0000269PubMed:16510840}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004620 phospholipase activity
GO:0004622 lysophospholipase activity
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047498 calcium-dependent phospholipase A2 activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0009395 phospholipid catabolic process
GO:0016042 lipid catabolic process
GO:0042127 regulation of cell proliferation
GO:0046456 icosanoid biosynthetic process
GO:0050482 arachidonic acid secretion
GO:0071236 cellular response to antibiotic
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR002642 Lysophospholipase, catalytic domain
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
PFAM PF00168
PF01735
PRINTS PR00360
PIRSF
SMART SM00239
SM00022
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A4IFJ5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 525072
UniGene Bt.69446
RefSeq NP_001069332
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY363688 BC134610
GenPept AAI34611 AAR17479

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca