Version 5.4
| Bos taurus Gene: PLA2G4A | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||||
| InnateDB Gene | IDBG-637785.3 | ||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
| Gene Symbol | PLA2G4A | ||||||||||||||||||||
| Gene Name | Cytosolic phospholipase A2 Phospholipase A2 Lysophospholipase | ||||||||||||||||||||
| Synonyms | |||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000013298 | ||||||||||||||||||||
| Encoded Proteins |
Cytosolic phospholipase A2Phospholipase A2Lysophospholipase
|
||||||||||||||||||||
| Protein Structure |
|
||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||
| Summary |
[Homo sapiens] PLA2G4A and its metabolite lipid mediators induce autophagy in macrophages and monocytes. This autophagy is ATG5 dependent and independent of changes in mTOR or autophagic flux. (Demonstrated in mice)
[Mus musculus] Pla2g4a and its metabolite lipid mediators induce autophagy in macrophages and monocytes. This autophagy is Atg5 dependent and independent of changes in mTOR or autophagic flux.
|
||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116711:
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008] |
||||||||||||||||||||
| Gene Information | |||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||
| Genomic Location | Chromosome 16:69443238-69620712 | ||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||
| Band | |||||||||||||||||||||
| Transcripts |
|
||||||||||||||||||||
| Interactions | |||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
|
||||||||||||||||||||
| Gene Ontology | |||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||
| Biological Process |
|
||||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||||
| Orthologs | |||||||||||||||||||||
|
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||||||||||
| Pathways | |||||||||||||||||||||
| NETPATH | |||||||||||||||||||||
| REACTOME |
Arachidonic acid metabolism pathway
Synthesis of PA pathway
Platelet sensitization by LDL pathway
Acyl chain remodelling of PC pathway
Signaling by GPCR pathway
Glycerophospholipid biosynthesis pathway
Acyl chain remodeling of CL pathway
Acyl chain remodelling of PI pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Signal amplification pathway
G-protein mediated events pathway
Platelet homeostasis pathway
Metabolism of lipids and lipoproteins pathway
Hydrolysis of LPC pathway
ADP signalling through P2Y purinoceptor 1 pathway
PLC beta mediated events pathway
Metabolism pathway
phospho-PLA2 pathway pathway
Acyl chain remodelling of PS pathway
Phospholipid metabolism pathway
Opioid Signalling pathway
Ca-dependent events pathway
Acyl chain remodelling of PE pathway
Acyl chain remodelling of PG pathway
|
||||||||||||||||||||
| KEGG | |||||||||||||||||||||
| INOH | |||||||||||||||||||||
| PID NCI | |||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||
| NETPATH |
IL1 pathway
IL5 pathway
|
||||||||||||||||||||
| REACTOME |
Platelet sensitization by LDL pathway
Platelet homeostasis pathway
ADP signalling through P2Y purinoceptor 1 pathway
phospho-PLA2 pathway pathway
PLC beta mediated events pathway
Opioid Signalling pathway
Arachidonic acid metabolism pathway
Acyl chain remodelling of PC pathway
Acyl chain remodelling of PI pathway
Hydrolysis of LPC pathway
Acyl chain remodelling of PS pathway
Synthesis of PA pathway
Acyl chain remodelling of PG pathway
Acyl chain remodelling of PE pathway
Acyl chain remodeling of CL pathway
Metabolism of lipids and lipoproteins pathway
Signaling by GPCR pathway
Glycerophospholipid biosynthesis pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
G-protein mediated events pathway
Phospholipid metabolism pathway
Metabolism pathway
Signal amplification pathway
Ca-dependent events pathway
Hemostasis pathway
Acyl chain remodelling of PC pathway
Acyl chain remodelling of PG pathway
Acyl chain remodelling of PS pathway
Acyl chain remodeling of CL pathway
Platelet homeostasis pathway
Hemostasis pathway
Signaling by GPCR pathway
Hydrolysis of LPC pathway
Acyl chain remodelling of PE pathway
Acyl chain remodelling of PI pathway
Ca-dependent events pathway
phospho-PLA2 pathway pathway
Metabolism pathway
Platelet activation, signaling and aggregation pathway
Metabolism of lipids and lipoproteins pathway
Platelet sensitization by LDL pathway
ADP signalling through P2Y purinoceptor 1 pathway
Glycerophospholipid biosynthesis pathway
Synthesis of PA pathway
Phospholipid metabolism pathway
Opioid Signalling pathway
Signal Transduction pathway
PLC beta mediated events pathway
Signal amplification pathway
G-protein mediated events pathway
Arachidonic acid metabolism pathway
|
||||||||||||||||||||
| KEGG |
alpha-Linolenic acid metabolism pathway
GnRH signaling pathway pathway
Arachidonic acid metabolism pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
MAPK signaling pathway pathway
Glycerophospholipid metabolism pathway
Linoleic acid metabolism pathway
Long-term depression pathway
Ether lipid metabolism pathway
Fc gamma R-mediated phagocytosis pathway
Vascular smooth muscle contraction pathway
Glycerophospholipid metabolism pathway
VEGF signaling pathway pathway
Arachidonic acid metabolism pathway
Ether lipid metabolism pathway
Fc epsilon RI signaling pathway pathway
GnRH signaling pathway pathway
Linoleic acid metabolism pathway
MAPK signaling pathway pathway
alpha-Linolenic acid metabolism pathway
Long-term depression pathway
Fc gamma R-mediated phagocytosis pathway
Vascular smooth muscle contraction pathway
|
||||||||||||||||||||
| INOH | |||||||||||||||||||||
| PID NCI |
Endothelins
Signaling mediated by p38-alpha and p38-beta
Fc-epsilon receptor I signaling in mast cells
PDGFR-beta signaling pathway
|
||||||||||||||||||||
| Cross-References | |||||||||||||||||||||
| SwissProt | A4IFJ5 | ||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||
| Entrez Gene | 525072 | ||||||||||||||||||||
| UniGene | Bt.105992 Bt.63740 Bt.69446 | ||||||||||||||||||||
| RefSeq | NM_001075864 XM_005194904 | ||||||||||||||||||||
| HUGO | |||||||||||||||||||||
| OMIM | |||||||||||||||||||||
| CCDS | |||||||||||||||||||||
| HPRD | |||||||||||||||||||||
| IMGT | |||||||||||||||||||||
| EMBL | AY363688 BC134610 | ||||||||||||||||||||
| GenPept | AAI34611 AAR17479 | ||||||||||||||||||||
| RNA Seq Atlas | 525072 | ||||||||||||||||||||