Version 5.4
Bos taurus Protein: TRIB2
Summary
InnateDB Protein IDBP-689873.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIB2
Protein Name Tribbles homolog 2
Synonyms TRB-2; TRB2;
Species Bos taurus
Ensembl Protein ENSBTAP00000021347
InnateDB Gene IDBG-637840 (TRIB2)
Protein Structure
UniProt Annotation
Function Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). {ECO:0000250UniProtKB:Q28283, ECO:0000250UniProtKB:Q96RU8}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=May associate with the cytoskeleton. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in granulosa cells of the dominant follicles of the ovary and down-regulated in ovulatory follicles. {ECO:0000269PubMed:15829623}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004860 protein kinase inhibitor activity
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031625 ubiquitin protein ligase binding
GO:0055106 ubiquitin-protein ligase regulator activity
Biological Process
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0008152 metabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043405 regulation of MAP kinase activity
GO:0045081 negative regulation of interleukin-10 biosynthetic process
GO:0045599 negative regulation of fat cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5GLH2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 352960
UniGene Bt.65787
RefSeq NP_847887
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY247741 AY360147 BC123595
GenPept AAI23596 AAP04410 AAR12274

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca