InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TRIB2

Summary

InnateDB Gene

IDBG-637840.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIB2

Gene Name

Tribbles homolog 2

Synonyms

TRB-2; TRB2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016045

Encoded Proteins

IDBP-689873

Tribbles homolog 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22271508

[Homo sapiens] TRIB2 expression is induced by TLR5 stimulation to inhibit NF-kB signalling in epithelial cells.

PMID 22271508

[Mus musculus] Trib2 expression is induced by Tlr5 stimulation to inhibit NF-kB signalling in epithelial cells.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071575:
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:85205522-85233638

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000021347

ENSBTAP00000021347

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004860	protein kinase inhibitor activity
GO:0005524	ATP binding
GO:0008134	transcription factor binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031625	ubiquitin protein ligase binding
GO:0055106	ubiquitin-protein ligase regulator activity

Biological Process

GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0008152	metabolic process
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043405	regulation of MAP kinase activity
GO:0045081	negative regulation of interleukin-10 biosynthetic process
GO:0045599	negative regulation of fat cell differentiation

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000071575

View Gene Order

ENSMUSG00000020601

View Gene Order

Cross-References

SwissProt

Q5GLH2

TrEMBL

UniProt Splice Variant

Entrez Gene

352960

UniGene

Bt.22857 Bt.65787

RefSeq

NM_178317

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY247741 AY360147 BC123595

GenPept

AAI23596 AAP04410 AAR12274

RNA Seq Atlas

352960