InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: AKT2

Summary

InnateDB Protein

IDBP-689920.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKT2

Protein Name

v-akt murine thymoma viral oncogene homolog 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000001839

InnateDB Gene

IDBG-637808 (AKT2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0008286	insulin receptor signaling pathway
GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport
GO:0010907	positive regulation of glucose metabolic process
GO:0016310	phosphorylation
GO:0031340	positive regulation of vesicle fusion
GO:0032000	positive regulation of fatty acid beta-oxidation
GO:0032287	peripheral nervous system myelin maintenance
GO:0032859	activation of Ral GTPase activity
GO:0032869	cellular response to insulin stimulus
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0046326	positive regulation of glucose import
GO:0065002	intracellular protein transmembrane transport
GO:0072659	protein localization to plasma membrane
GO:0090314	positive regulation of protein targeting to membrane
GO:2000147	positive regulation of cell motility
GO:2001275	positive regulation of glucose import in response to insulin stimulus

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0032587	ruffle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001849 Pleckstrin homology domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00169
PF00433

PRINTS

PR00109

PIRSF

SMART

SM00133
SM00233
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt