InnateDB Protein
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IDBP-68997.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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YAP1
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Protein Name
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Yes-associated protein 1
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Synonyms
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COB1; YAP; YAP2; YAP65; YKI;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000282441
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InnateDB Gene
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IDBG-68995 (YAP1)
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Protein Structure
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Function |
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3). {ECO:0000269PubMed:12807903, ECO:0000269PubMed:17974916, ECO:0000269PubMed:18158288, ECO:0000269PubMed:18280240, ECO:0000269PubMed:18579750, ECO:0000269PubMed:21364637}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=Both phosphorylation and cell density can regulate its subcellular localization. Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus. At low density, predominantly nuclear and is translocated to the cytoplasm at high density. PTPN14 induces translocation from the nucleus to the cytoplasm.
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Disease Associations |
Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation (COCLEMR) [MIM:120433]: An autosomal dominant disease characterized by uveal colobomata, microphthalmia, cataract and cleft lip/palate. Considerable variability is observed among patients, uveal colobomata being the most constant feature. Some patients manifest mental retardation of varying degree and/or sensorineural, mid- frequency hearing loss. {ECO:0000269PubMed:24462371}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level). {ECO:0000269PubMed:16461361, ECO:0000269PubMed:17974916, ECO:0000269PubMed:7782338}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
161
[view]
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Protein-Protein |
158
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
2
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001202
WW domain
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PFAM |
PF00397
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PRINTS |
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PIRSF |
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SMART |
SM00456
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TIGRFAMs |
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Modification |
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SwissProt |
P46937
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PhosphoSite |
PhosphoSite-P46937
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
10413
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UniGene |
Hs.737025
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RefSeq |
NP_001123617
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HUGO |
HGNC:16262
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OMIM |
606608
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CCDS |
CCDS44716
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HPRD |
09424
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IMGT |
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EMBL |
AB567720
AB567721
AK300414
AK316116
AP000942
AP001527
AP002777
AY316529
BC038235
CH471065
HE864159
HE864160
HE864161
HE864162
X80507
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GenPept |
AAH38235
AAP92710
BAG62143
BAH14487
BAJ41471
BAJ41472
CAA56672
CCI79618
CCI79619
CCI79620
CCI79621
EAW67011
EAW67015
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