InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CASK

Summary

InnateDB Protein

IDBP-689978.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASK

Protein Name

peripheral plasma membrane protein CASK

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026825

InnateDB Gene

IDBG-637908 (CASK)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042043	neurexin family protein binding

Biological Process

GO:0001953	negative regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0010839	negative regulation of keratinocyte proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0061045	negative regulation of wound healing
GO:0070509	calcium ion import
GO:0090280	positive regulation of calcium ion import
GO:0090288	negative regulation of cellular response to growth factor stimulus

Cellular Component

GO:0005604	basement membrane
GO:0005634	nucleus
GO:0005652	nuclear lamina
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016363	nuclear matrix
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR001478 PDZ domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR004172 L27
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR014775 L27, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM