Version 5.4
Bos taurus Protein: UBE2T
Summary
InnateDB Protein IDBP-690005.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2T
Protein Name ubiquitin-conjugating enzyme E2 T
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000006290
InnateDB Gene IDBG-637970 (UBE2T)
Protein Structure
UniProt Annotation
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Accumulates to chromatin. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003682 chromatin binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006281 DNA repair
GO:0006513 protein monoubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0016567 protein ubiquitination
GO:0035519 protein K29-linked ubiquitination
GO:0044314 protein K27-linked ubiquitination
GO:0051865 protein autoubiquitination
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0085020 protein K6-linked ubiquitination
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
PFAM PF00179
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q32LD2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 505314
UniGene Bt.2915
RefSeq NP_001033123
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC109637 DAAA02043707
GenPept AAI09638

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca