|
InnateDB Protein
|
IDBP-690011.2
|
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
|
Gene Symbol
|
PLSCR2
|
|
Protein Name
|
Phospholipid scramblase 2
|
|
Synonyms
|
PLSCR2;
|
|
Species
|
Bos taurus
|
|
Ensembl Protein
|
ENSBTAP00000029993
|
|
InnateDB Gene
|
IDBG-637967 (PLSCR2)
|
|
Protein Structure
|
|
| Function |
May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system (By similarity). {ECO:0000250}.
|
| Subcellular Localization |
Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Disease Associations |
|
| Tissue Specificity |
|
| Comments |
|
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.
|
|
| Predicted by orthology |
| Total |
72 [view]
|
|
|
Molecular Function |
|
| Biological Process |
|
| Cellular Component |
|
| PDB ID |
|
| InterPro |
IPR005552
Scramblase
IPR025659
Tubby C-terminal-like domain
|
| PFAM |
PF03803
|
| PRINTS |
|
| PIRSF |
|
| SMART |
|
| TIGRFAMs |
|
| Modification |
|
| SwissProt |
Q3ZBG9
|
| PhosphoSite |
PhosphoSite-
|
| TrEMBL |
|
| UniProt Splice Variant |
|
| Entrez Gene |
513193
|
| UniGene |
Bt.96910
|
| RefSeq |
NP_001029608
|
| HUGO |
|
| OMIM |
|
| CCDS |
|
| HPRD |
|
| IMGT |
|
| EMBL |
BC103299
|
| GenPept |
AAI03300
|
|
|
|
Version 5.4