InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CNTF

Summary

InnateDB Protein

IDBP-690013.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNTF

Protein Name

ciliary neurotrophic factor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004729

InnateDB Gene

IDBG-637978 (CNTF)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005138	interleukin-6 receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0040007	growth
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043524	negative regulation of neuron apoptotic process
GO:0046533	negative regulation of photoreceptor cell differentiation
GO:0046668	regulation of retinal cell programmed cell death
GO:0048644	muscle organ morphogenesis
GO:0048666	neuron development
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0097058	CRLF-CLCF1 complex

Protein Structure and Domains

PDB ID

InterPro

IPR000151 Ciliary neurotrophic factor, CNTF
IPR009079 Four-helical cytokine-like, core

PFAM

PF01110

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E1BFH9

UniProt Splice Variant

Entrez Gene

100848228

UniGene

RefSeq

XP_003583242

HUGO

HGNC:2169

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02041806

GenPept