Version 5.4
Bos taurus Protein: GADD45A
Summary
InnateDB Protein IDBP-690134.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GADD45A
Protein Name Growth arrest and DNA damage-inducible protein GADD45 alpha
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000033363
InnateDB Gene IDBG-638096 (GADD45A)
Protein Structure
UniProt Annotation
Function Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.
Predicted by orthology
Total 69 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0005515 protein binding
Biological Process
GO:0000185 activation of MAPKKK activity
GO:0006469 negative regulation of protein kinase activity
GO:0006950 response to stress
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007050 cell cycle arrest
GO:0007098 centrosome cycle
GO:0042770 signal transduction in response to DNA damage
GO:0043065 positive regulation of apoptotic process
GO:0046330 positive regulation of JNK cascade
GO:0051726 regulation of cell cycle
GO:0071260 cellular response to mechanical stimulus
GO:0071479 cellular response to ionizing radiation
GO:1900745 positive regulation of p38MAPK cascade
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
IPR029064 50S ribosomal protein L30e-like
PFAM PF01248
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZBN6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 505463
UniGene
RefSeq NP_001029419
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103198
GenPept AAI03199

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca