InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GADD45A

Summary

InnateDB Gene

IDBG-638096.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GADD45A

Gene Name

Growth arrest and DNA damage-inducible protein GADD45 alpha

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013860

Encoded Proteins

IDBP-690134

Growth arrest and DNA damage-inducible protein GADD45 alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116717:
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:77972153-77975265

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000033450

ENSBTAP00000033363

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0005515	protein binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0006469	negative regulation of protein kinase activity
GO:0006950	response to stress
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0007050	cell cycle arrest
GO:0007098	centrosome cycle
GO:0042770	signal transduction in response to DNA damage
GO:0043065	positive regulation of apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0051726	regulation of cell cycle
GO:0071260	cellular response to mechanical stimulus
GO:0071479	cellular response to ionizing radiation
GO:1900745	positive regulation of p38MAPK cascade
GO:2000379	positive regulation of reactive oxygen species metabolic process