Version 5.4
Bos taurus Protein: NR0B1
Summary
InnateDB Protein IDBP-690339.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NR0B1
Protein Name nuclear receptor subfamily 0, group B, member 1
Synonyms DAX-1;
Species Bos taurus
Ensembl Protein ENSBTAP00000020641
InnateDB Gene IDBG-638274 (NR0B1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
GO:0032448 DNA hairpin binding
GO:0035258 steroid hormone receptor binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0050682 AF-2 domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006694 steroid biosynthetic process
GO:0007283 spermatogenesis
GO:0007530 sex determination
GO:0008104 protein localization
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0030154 cell differentiation
GO:0030238 male sex determination
GO:0030325 adrenal gland development
GO:0030522 intracellular receptor signaling pathway
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033327 Leydig cell differentiation
GO:0035902 response to immobilization stress
GO:0043401 steroid hormone mediated signaling pathway
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045596 negative regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060008 Sertoli cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0042788 polysomal ribosome
Protein Structure and Domains
PDB ID
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding
PFAM PF00104
PRINTS PR00398
PIRSF
SMART SM00430
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G5E5I7
UniProt Splice Variant
Entrez Gene 281949
UniGene Bt.13026
RefSeq NP_001192786
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02073850
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca