Bos taurus Gene: NR0B1
InnateDB Gene IDBG-638274.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NR0B1
Gene Name nuclear receptor subfamily 0 group B member 1
Synonyms DAX-1
Species Bos taurus
Ensembl Gene ENSBTAG00000015532
Encoded Proteins
nuclear receptor subfamily 0, group B, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169297:
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:118534503-118540311
Strand Forward strand
ENSBTAT00000020641 ENSBTAP00000020641
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
GO:0032448 DNA hairpin binding
GO:0035258 steroid hormone receptor binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0050682 AF-2 domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006694 steroid biosynthetic process
GO:0007283 spermatogenesis
GO:0007530 sex determination
GO:0008104 protein localization
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0030154 cell differentiation
GO:0030238 male sex determination
GO:0030325 adrenal gland development
GO:0030522 intracellular receptor signaling pathway
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033327 Leydig cell differentiation
GO:0035902 response to immobilization stress
GO:0043401 steroid hormone mediated signaling pathway
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045596 negative regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060008 Sertoli cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0042788 polysomal ribosome
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
Nuclear Receptor transcription pathway pathway
Gene Expression pathway
Generic Transcription Pathway pathway
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Regulation of Androgen receptor activity
UniProt Splice Variant
Entrez Gene
UniGene Bt.13026
RefSeq NM_001205857
RNA Seq Atlas