InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NR0B1

Summary

InnateDB Gene

IDBG-638274.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR0B1

Gene Name

nuclear receptor subfamily 0 group B member 1

Synonyms

DAX-1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015532

Encoded Proteins

IDBP-690339

nuclear receptor subfamily 0, group B, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169297:
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:118534503-118540311

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020641

ENSBTAP00000020641

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0003714	transcription corepressor activity
GO:0003723	RNA binding
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding
GO:0032448	DNA hairpin binding
GO:0035258	steroid hormone receptor binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0050682	AF-2 domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006694	steroid biosynthetic process
GO:0007283	spermatogenesis
GO:0007530	sex determination
GO:0008104	protein localization
GO:0008406	gonad development
GO:0008584	male gonad development
GO:0030154	cell differentiation
GO:0030238	male sex determination
GO:0030325	adrenal gland development
GO:0030522	intracellular receptor signaling pathway
GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033327	Leydig cell differentiation
GO:0035902	response to immobilization stress
GO:0043401	steroid hormone mediated signaling pathway
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045596	negative regulation of cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060008	Sertoli cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0042788	polysomal ribosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000169297

View Gene Order

ENSMUSG00000025056

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_234105

Nuclear Receptor transcription pathway pathway

REACT_233572

Gene Expression pathway

REACT_206529

Generic Transcription Pathway pathway

KEGG

INOH

PID NCI

erb_genomic_pathway

Validated nuclear estrogen receptor beta network

era_genomic_pathway

Validated nuclear estrogen receptor alpha network

ar_tf_pathway

Regulation of Androgen receptor activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.13026

RefSeq

NM_001205857

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas