InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SAT1

Summary

InnateDB Protein

IDBP-690496.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAT1

Protein Name

Diamine acetyltransferase 1

Synonyms

SAT;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023087

InnateDB Gene

IDBG-638429 (SAT1)

Protein Structure

UniProt Annotation

Function

Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.

Predicted by orthology
Total	54 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004145	diamine N-acetyltransferase activity
GO:0005515	protein binding
GO:0008080	N-acetyltransferase activity
GO:0016740	transferase activity
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0001525	angiogenesis
GO:0008152	metabolic process
GO:0009447	putrescine catabolic process
GO:0042127	regulation of cell proliferation

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000182 GNAT domain
IPR016181 Acyl-CoA N-acyltransferase

PFAM

PF00583
PF13302
PF13508
PF13673
PF13718

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3T0Q0

PhosphoSite

PhosphoSite-

TrEMBL

F7VJJ0

UniProt Splice Variant

Entrez Gene

508861

UniGene

Bt.97768

RefSeq

NP_001029505

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102304 BK001352

GenPept

AAI02305 DAA34836