InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KNG1

Summary

InnateDB Protein

IDBP-69063.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KNG1

Protein Name

kininogen 1

Synonyms

BDK; BK; KNG;

Species

Homo sapiens

Ensembl Protein

ENSP00000265023

InnateDB Gene

IDBG-69059 (KNG1)

Protein Structure

UniProt Annotation

Function

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

High molecular weight kininogen deficiency (HMWK deficiency) [MIM:228960]: Autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors. {ECO:0000269PubMed:2076202}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008270	zinc ion binding

Biological Process

GO:0002576	platelet degranulation
GO:0006939	smooth muscle contraction
GO:0006954	inflammatory response
GO:0007162	negative regulation of cell adhesion
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0010951	negative regulation of endopeptidase activity
GO:0030168	platelet activation
GO:0030195	negative regulation of blood coagulation
GO:0035810	positive regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0042311	vasodilation
GO:0043065	positive regulation of apoptotic process
GO:0045861	negative regulation of proteolysis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle