InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KNG1

Summary

InnateDB Gene

IDBG-69059.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KNG1

Gene Name

kininogen 1

Synonyms

BDK; BK; KNG

Species

Homo sapiens

Ensembl Gene

ENSG00000113889

Encoded Proteins

IDBP-69061

kininogen 1

IDBP-69063

kininogen 1

IDBP-386411

kininogen 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:186717276-186743954

Strand

Forward strand

Band

q27.3

Transcripts

ENST00000287611	ENSP00000287611
ENST00000265023	ENSP00000265023
ENST00000447445	ENSP00000396025

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008270	zinc ion binding

Biological Process

GO:0002576	platelet degranulation
GO:0006939	smooth muscle contraction
GO:0006954	inflammatory response
GO:0007162	negative regulation of cell adhesion
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0010951	negative regulation of endopeptidase activity
GO:0030168	platelet activation
GO:0030195	negative regulation of blood coagulation
GO:0035810	positive regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0042311	vasodilation
GO:0043065	positive regulation of apoptotic process
GO:0045861	negative regulation of proteolysis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle