Version 5.4
Bos taurus Protein: NCK1
Summary
InnateDB Protein IDBP-690743.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCK1
Protein Name cytoplasmic protein NCK1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024518
InnateDB Gene IDBG-638662 (NCK1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 206 interaction(s) predicted by orthology.
Predicted by orthology
Total 206 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004860 protein kinase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0019887 protein kinase regulator activity
GO:0019904 protein domain specific binding
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0006469 negative regulation of protein kinase activity
GO:0007015 actin filament organization
GO:0016477 cell migration
GO:0030032 lamellipodium assembly
GO:0030838 positive regulation of actin filament polymerization
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051707 response to other organism
GO:0060548 negative regulation of cell death
Cellular Component
GO:0005911 cell-cell junction
GO:0012506 vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR001452 SH3 domain
IPR011511 Variant SH3 domain
IPR017304 Cytoplasmic protein NCK
PFAM PF00017
PF14633
PF00018
PF14604
PF07653
PRINTS PR00401
PR00452
PIRSF PIRSF037874
SMART SM00252
SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q1LZB2
UniProt Splice Variant
Entrez Gene 536154
UniGene Bt.46490
RefSeq NP_001069540
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116109 DAAA02002998
GenPept AAI16110

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca