Version 5.4
Bos taurus Protein: PHB
Summary
InnateDB Protein IDBP-690913.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHB
Protein Name Prohibitin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000022759
InnateDB Gene IDBG-638810 (PHB)
Protein Structure
UniProt Annotation
Function Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.
Predicted by orthology
Total 78 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042826 histone deacetylase binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001649 osteoblast differentiation
GO:0006260 DNA replication
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0008285 negative regulation of cell proliferation
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0016575 histone deacetylation
GO:0030308 negative regulation of cell growth
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0050847 progesterone receptor signaling pathway
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0071354 cellular response to interleukin-6
GO:0071897 DNA biosynthetic process
GO:2000323 negative regulation of glucocorticoid receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000163 Prohibitin
IPR001107 Band 7 protein
PFAM PF01145
PRINTS PR00679
PIRSF
SMART SM00244
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3T165
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 530409
UniGene Bt.88344
RefSeq NP_001029744
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102094
GenPept AAI02095

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca