InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PHB

Summary

InnateDB Gene

IDBG-638810.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHB

Gene Name

Prohibitin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017120

Encoded Proteins

IDBP-690913

Prohibitin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167085:
Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA. [provided by RefSeq, Jul 2008]
This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3\' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:37828780-37839397

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022759

ENSBTAP00000022759

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0042826	histone deacetylase binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001649	osteoblast differentiation
GO:0006260	DNA replication
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0008285	negative regulation of cell proliferation
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0016575	histone deacetylation
GO:0030308	negative regulation of cell growth
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050847	progesterone receptor signaling pathway
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0071354	cellular response to interleukin-6
GO:0071897	DNA biosynthetic process
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000167085

View Gene Order

ENSMUSG00000038845

View Gene Order

Cross-References

SwissProt

Q3T165

TrEMBL

UniProt Splice Variant

Entrez Gene

530409

UniGene

Bt.61926 Bt.88344

RefSeq

NM_001034572 XM_005220569 XM_005220570

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102094

GenPept

AAI02095

RNA Seq Atlas

530409