InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ACE2

Summary

InnateDB Protein

IDBP-691016.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACE2

Protein Name

Angiotensin-converting enzyme 2Processed angiotensin-converting enzyme 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000045721

InnateDB Gene

IDBG-638902 (ACE2)

Protein Structure

UniProt Annotation

Function

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function (By similarity). {ECO:0000250}.

Subcellular Localization

Processed angiotensin-converting enzyme 2: Secreted {ECO:0000250}.Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0001948	glycoprotein binding
GO:0004175	endopeptidase activity
GO:0004180	carboxypeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008241	peptidyl-dipeptidase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0003051	angiotensin-mediated drinking behavior
GO:0006508	proteolysis
GO:0009615	response to virus
GO:0032800	receptor biosynthetic process
GO:0046813	receptor-mediated virion attachment to host cell

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001548 Peptidase M2, peptidyl-dipeptidase A

PFAM

PF01401

PRINTS

PR00791

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q58DD0

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

509235

UniGene

Bt.88861

RefSeq

NP_001019673

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BT021667

GenPept

AAX46514