Version 5.4
Bos taurus Protein: ETHE1
Summary
InnateDB Protein IDBP-691126.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ETHE1
Protein Name Protein ETHE1, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000005747
InnateDB Gene IDBG-639008 (ETHE1)
Protein Structure
UniProt Annotation
Function Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0050313 sulfur dioxygenase activity
GO:0051213 dioxygenase activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0055114 oxidation-reduction process
GO:0070813 hydrogen sulfide metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID
InterPro IPR001279 Beta-lactamase-like
PFAM PF00753
PRINTS
PIRSF
SMART SM00849
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3T094
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 509150
UniGene Bt.48849
RefSeq NP_001029516
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102496
GenPept AAI02497

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca