Version 5.4
Bos taurus Protein: LIMS2
Summary
InnateDB Protein IDBP-691245.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIMS2
Protein Name LIM and senescent cell antigen-like-containing domain protein 2
Synonyms LIMS1;
Species Bos taurus
Ensembl Protein ENSBTAP00000008216
InnateDB Gene IDBG-639117 (LIMS2)
Protein Structure
UniProt Annotation
Function Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. {ECO:0000250}.
Subcellular Localization Cell junction, focal adhesion {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0016337 single organismal cell-cell adhesion
GO:0043066 negative regulation of apoptotic process
GO:0045216 cell-cell junction organization
GO:0050680 negative regulation of epithelial cell proliferation
GO:2000178 negative regulation of neural precursor cell proliferation
GO:2000346 negative regulation of hepatocyte proliferation
GO:2001046 positive regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0030054 cell junction
Protein Structure and Domains
PDB ID
InterPro IPR001781 Zinc finger, LIM-type
IPR017351 LIM and senescent cell antigen-like-containing domain protein 1
PFAM PF00412
PRINTS
PIRSF PIRSF038003
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KJ33
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 515401
UniGene Bt.32348
RefSeq NP_001124223
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105544
GenPept AAI05545

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca