Version 5.4
Bos taurus Gene: LIMS2
Summary
InnateDB Gene IDBG-639117.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIMS2
Gene Name LIM and senescent cell antigen-like-containing domain protein 2
Synonyms LIMS1
Species Bos taurus
Ensembl Gene ENSBTAG00000006262
Encoded Proteins
IDBP-691245
LIM and senescent cell antigen-like-containing domain protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072163:
This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:4780176-4819192
Strand Forward strand
Band
Transcripts
ENSBTAT00000008216 ENSBTAP00000008216
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0016337 single organismal cell-cell adhesion
GO:0043066 negative regulation of apoptotic process
GO:0045216 cell-cell junction organization
GO:0050680 negative regulation of epithelial cell proliferation
GO:2000178 negative regulation of neural precursor cell proliferation
GO:2000346 negative regulation of hepatocyte proliferation
GO:2001046 positive regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0030054 cell junction
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000072163
View Gene Order
ENSMUSG00000024395
View Gene Order
Pathways
NETPATH
REACTOME
REACT_214866
Cell junction organization pathway
REACT_206475
Cell-Cell communication pathway
REACT_213279
Cell-extracellular matrix interactions pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
KEGG
INOH
PID NCI
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt Q2KJ33
TrEMBL
UniProt Splice Variant
Entrez Gene 515401
UniGene Bt.32348
RefSeq NM_001130751 XM_005202197 XM_005202198
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105544
GenPept AAI05545
RNA Seq Atlas 515401

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca