InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ATP2C1

Summary

InnateDB Protein

IDBP-691250.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP2C1

Protein Name

Calcium-transporting ATPase type 2C member 1

Synonyms

SPCA;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015441

InnateDB Gene

IDBG-639111 (ATP2C1)

Protein Structure

UniProt Annotation

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004871	signal transducer activity
GO:0005388	calcium-transporting ATPase activity
GO:0005509	calcium ion binding
GO:0005524	ATP binding
GO:0015410	manganese-transporting ATPase activity
GO:0016787	hydrolase activity
GO:0019829	cation-transporting ATPase activity
GO:0030145	manganese ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006828	manganese ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0008544	epidermis development
GO:0016339	calcium-dependent cell-cell adhesion
GO:0030026	cellular manganese ion homeostasis
GO:0031532	actin cytoskeleton reorganization
GO:0032468	Golgi calcium ion homeostasis
GO:0032472	Golgi calcium ion transport
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0070588	calcium ion transmembrane transport
GO:0071421	manganese ion transmembrane transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001757 Cation-transporting P-type ATPase
IPR004014 Cation-transporting P-type ATPase, N-terminal
IPR006068 Cation-transporting P-type ATPase, C-terminal
IPR006413 Calcium-transporting P-type ATPase, subfamily IIA, PMR1-type
IPR008250 P-type ATPase, A domain
IPR023214 HAD-like domain
IPR023299 P-type ATPase, cytoplasmic domain N

PFAM

PF00690
PF00689
PF00122
PF00702
PF08282
PF13419

PRINTS

PR00119
PR00120

PIRSF

SMART

SM00831

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P57709

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

327663

UniGene

Bt.269

RefSeq

NP_786979

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AF230532

GenPept

AAF64433