InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATP2C1

Summary

InnateDB Gene

IDBG-639111.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP2C1

Gene Name

Calcium-transporting ATPase type 2C member 1

Synonyms

SPCA

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011626

Encoded Proteins

IDBP-691250

Calcium-transporting ATPase type 2C member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000017260:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:140368053-140522639

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015441

ENSBTAP00000015441

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004871	signal transducer activity
GO:0005388	calcium-transporting ATPase activity
GO:0005509	calcium ion binding
GO:0005524	ATP binding
GO:0015410	manganese-transporting ATPase activity
GO:0016787	hydrolase activity
GO:0019829	cation-transporting ATPase activity
GO:0030145	manganese ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0006828	manganese ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0008544	epidermis development
GO:0016339	calcium-dependent cell-cell adhesion
GO:0030026	cellular manganese ion homeostasis
GO:0031532	actin cytoskeleton reorganization
GO:0032468	Golgi calcium ion homeostasis
GO:0032472	Golgi calcium ion transport
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0070588	calcium ion transmembrane transport
GO:0071421	manganese ion transmembrane transport