InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ERCC1

Summary

InnateDB Protein

IDBP-691633.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ERCC1

Protein Name

DNA excision repair protein ERCC-1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023078

InnateDB Gene

IDBG-639466 (ERCC1)

Protein Structure

UniProt Annotation

Function

Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000014	single-stranded DNA endodeoxyribonuclease activity
GO:0001094	TFIID-class transcription factor binding
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003697	single-stranded DNA binding
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0016787	hydrolase activity
GO:0017025	TBP-class protein binding
GO:0019904	protein domain specific binding
GO:0043566	structure-specific DNA binding

Biological Process

GO:0000720	pyrimidine dimer repair by nucleotide-excision repair
GO:0000737	DNA catabolic process, endonucleolytic
GO:0001302	replicative cell aging
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0006312	mitotic recombination
GO:0006949	syncytium formation
GO:0006974	cellular response to DNA damage stimulus
GO:0006979	response to oxidative stress
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0008584	male gonad development
GO:0009650	UV protection
GO:0010165	response to X-ray
GO:0010259	multicellular organismal aging
GO:0032205	negative regulation of telomere maintenance
GO:0035166	post-embryonic hemopoiesis
GO:0035264	multicellular organism growth
GO:0036297	interstrand cross-link repair
GO:0045190	isotype switching
GO:0048468	cell development
GO:0048477	oogenesis
GO:0051276	chromosome organization

Cellular Component

GO:0000109	nucleotide-excision repair complex
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005669	transcription factor TFIID complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000445 Helix-hairpin-helix motif
IPR004579 DNA repair protein rad10
IPR010994 RuvA domain 2-like
IPR011335 Restriction endonuclease type II-like

PFAM

PF00633
PF03834

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q1LZ75

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

615637

UniGene

Bt.6079

RefSeq

NP_001069853

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC116163

GenPept

AAI16164