Version 5.4
Bos taurus Protein: GRB7
Summary
InnateDB Protein IDBP-691646.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRB7
Protein Name Growth factor receptor-bound protein 7
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000023091
InnateDB Gene IDBG-639472 (GRB7)
Protein Structure
UniProt Annotation
Function Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell projection {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Note=Predominantly cytoplasmic. Detected in stress granules where mRNA is stored under stress conditions (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0019901 protein kinase binding
GO:0035091 phosphatidylinositol binding
GO:0042802 identical protein binding
Biological Process
GO:0007165 signal transduction
GO:0017148 negative regulation of translation
GO:0030335 positive regulation of cell migration
GO:0034063 stress granule assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0030054 cell junction
GO:0042995 cell projection
Protein Structure and Domains
PDB ID
InterPro IPR000159 Ras-association
IPR000980 SH2 domain
IPR001849 Pleckstrin homology domain
IPR015042 BPS (Between PH and SH2) domain
IPR029071 Ubiquitin-related domain
PFAM PF00788
PF00017
PF14633
PF00169
PF08947
PRINTS PR00401
PIRSF
SMART SM00314
SM00252
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1RMW5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 508847
UniGene Bt.2949
RefSeq NP_001039479
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114669
GenPept AAI14670

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca