Version 5.4
Bos taurus Protein: FUS
Summary
InnateDB Protein IDBP-691747.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FUS
Protein Name RNA-binding protein FUS
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000007571
InnateDB Gene IDBG-639574 (FUS)
Protein Structure
UniProt Annotation
Function Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Note=Nuclear, exhibits diffuse staining throughout (excluding nucleoli), together with a small number of intensely stained focal points, or granules, and punctate staining along the nuclear envelope.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 82 interaction(s) predicted by orthology.
Predicted by orthology
Total 82 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR001876 Zinc finger, RanBP2-type
PFAM PF00076
PF00641
PRINTS
PIRSF
SMART SM00360
SM00547
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q28009
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280796
UniGene Bt.2474
RefSeq NP_776337
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC119965 U26024
GenPept AAC13543 AAI19966

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca