Version 5.4
Bos taurus Protein: AIRE
Summary
InnateDB Protein IDBP-691867.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AIRE
Protein Name autoimmune regulator
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000031798
InnateDB Gene IDBG-639674 (AIRE)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Predicted by orthology
Total 54 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0044212 transcription regulatory region DNA binding
GO:0045182 translation regulator activity
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006417 regulation of translation
GO:0006959 humoral immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000770 SAND domain
IPR001965 Zinc finger, PHD-type
IPR004865 Sp100
IPR008087 Autoimmune regulator, AIRE
IPR010919 SAND domain-like
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger
PFAM PF01342
PF03172
PF00628
PRINTS PR01711
PIRSF
SMART SM00258
SM00249
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BIC4
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:360
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02003438 DAAA02003439
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca