Version 5.4
Bos taurus Protein: NCF1
Summary
InnateDB Protein IDBP-692080.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCF1
Protein Name Neutrophil cytosol factor 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000004279
InnateDB Gene IDBG-639883 (NCF1)
Protein Structure
UniProt Annotation
Function NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000269PubMed:10647999}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:10647999}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0016175 superoxide-generating NADPH oxidase activity
GO:0017124 SH3 domain binding
GO:0035091 phosphatidylinositol binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
Biological Process
GO:0001878 response to yeast
GO:0001909 leukocyte mediated cytotoxicity
GO:0002679 respiratory burst involved in defense response
GO:0006612 protein targeting to membrane
GO:0006691 leukotriene metabolic process
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0008283 cell proliferation
GO:0009617 response to bacterium
GO:0042554 superoxide anion generation
GO:0042742 defense response to bacterium
GO:0045730 respiratory burst
GO:0045986 negative regulation of smooth muscle contraction
GO:0050665 hydrogen peroxide biosynthetic process
GO:0050830 defense response to Gram-positive bacterium
GO:0050832 defense response to fungus
GO:0055114 oxidation-reduction process
GO:0070946 neutrophil mediated killing of gram-positive bacterium
GO:0070947 neutrophil mediated killing of fungus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0019898 extrinsic component of membrane
GO:0043020 NADPH oxidase complex
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
IPR001655 Neutrophil cytosol factor 1
IPR001683 Phox homologous domain
IPR011511 Variant SH3 domain
IPR015039 NADPH oxidase subunit p47Phox, C-terminal
PFAM PF00018
PF14604
PF00787
PF07653
PF08944
PRINTS PR00452
PR00498
PIRSF
SMART SM00326
SM00312
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O77774
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281345
UniGene Bt.142
RefSeq NP_776544
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF079302 BC103145 BT020852 BT021181
GenPept AAC82462 AAI03146 AAX08869 AAX31363

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca