Version 5.4
Bos taurus Protein: SAE1
Summary
InnateDB Protein IDBP-692178.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAE1
Protein Name SUMO-activating enzyme subunit 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003467
InnateDB Gene IDBG-639978 (SAE1)
Protein Structure
UniProt Annotation
Function The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008641 small protein activating enzyme activity
GO:0016874 ligase activity
GO:0019948 SUMO activating enzyme activity
GO:0043008 ATP-dependent protein binding
Biological Process
GO:0006464 cellular protein modification process
GO:0007346 regulation of mitotic cell cycle
GO:0016925 protein sumoylation
GO:0019950 SMT3-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR000011 Ubiquitin/SUMO-activating enzyme E1
IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR009036 Molybdenum cofactor biosynthesis, MoeB
PFAM PF00899
PRINTS PR01849
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2VE14
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 505512
UniGene Bt.10575
RefSeq NP_001075180
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133519
GenPept AAI33520

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca