InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: AVP

Summary

InnateDB Protein

IDBP-692354.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AVP

Protein Name

Vasopressin-neurophysin 2-copeptinArg-vasopressinNeurophysin 2Copeptin

Synonyms

AVP-NPII;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010555

InnateDB Gene

IDBG-640134 (AVP)

Protein Structure

UniProt Annotation

Function

Neurophysin 2 specifically binds vasopressin.Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004871	signal transducer activity
GO:0005179	hormone activity
GO:0005185	neurohypophyseal hormone activity
GO:0031894	V1A vasopressin receptor binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process

GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0010628	positive regulation of gene expression
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0042310	vasoconstriction
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050880	regulation of blood vessel size
GO:0070371	ERK1 and ERK2 cascade
GO:0070528	protein kinase C signaling
GO:0090201	negative regulation of release of cytochrome c from mitochondria

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

InterPro

IPR000981 Neurohypophysial hormone

PFAM

PF00184

PRINTS

PR00831

PIRSF

PIRSF001815

SMART

SM00003

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P01180

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

280728

UniGene

Bt.49210

RefSeq

NP_789824

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102897 M25645 V00113 X00503

GenPept

AAA30806 AAI02898 CAA23447 CAA25195