InnateDB Protein
|
IDBP-692359.2
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PHB2
|
Protein Name
|
Prohibitin-2
|
Synonyms
|
REA;
|
Species
|
Bos taurus
|
Ensembl Protein
|
ENSBTAP00000017442
|
InnateDB Gene
|
IDBG-640131 (PHB2)
|
Protein Structure
|
|
Function |
Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Mitochondrion inner membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Also cytoplasmic and nuclear. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
75 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006351
|
transcription, DNA-templated
|
GO:0006355
|
regulation of transcription, DNA-templated
|
GO:0033147
|
negative regulation of intracellular estrogen receptor signaling pathway
|
GO:0033600
|
negative regulation of mammary gland epithelial cell proliferation
|
GO:0045892
|
negative regulation of transcription, DNA-templated
|
GO:0060744
|
mammary gland branching involved in thelarche
|
GO:0060749
|
mammary gland alveolus development
|
GO:0060762
|
regulation of branching involved in mammary gland duct morphogenesis
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000163
Prohibitin
IPR001107
Band 7 protein
|
PFAM |
PF01145
|
PRINTS |
PR00679
|
PIRSF |
|
SMART |
SM00244
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q2HJ97
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
515363
|
UniGene |
Bt.59547
|
RefSeq |
NP_001039663
|
HUGO |
|
OMIM |
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
BC113241
|
GenPept |
AAI13242
|
|
|