Version 5.4
Bos taurus Gene: PHB2
Summary
InnateDB Gene IDBG-640131.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHB2
Gene Name Prohibitin-2
Synonyms REA
Species Bos taurus
Ensembl Gene ENSBTAG00000013123
Encoded Proteins
IDBP-692359
Prohibitin-2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000215021:
Gene Information
Type Protein coding
Genomic Location Chromosome 5:103853322-103857548
Strand Forward strand
Band
Transcripts
ENSBTAT00000017442 ENSBTAP00000017442
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.
Predicted by orthology
Total 75 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0033600 negative regulation of mammary gland epithelial cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0060744 mammary gland branching involved in thelarche
GO:0060749 mammary gland alveolus development
GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000004264
View Gene Order
ENSG00000215021
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt Q2HJ97
TrEMBL
UniProt Splice Variant
Entrez Gene 515363
UniGene Bt.59547
RefSeq NM_001046198
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC113241
GenPept AAI13242
RNA Seq Atlas 515363

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca