InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: STAT3

Summary

InnateDB Protein

IDBP-692440.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAT3

Protein Name

signal transducer and activator of transcription 3

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000028687

InnateDB Gene

IDBG-640197 (STAT3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 289 interaction(s) predicted by orthology.

Predicted by orthology
Total	289 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001659	temperature homeostasis
GO:0001754	eye photoreceptor cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006606	protein import into nucleus
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0016310	phosphorylation
GO:0019827	stem cell maintenance
GO:0019953	sexual reproduction
GO:0030522	intracellular receptor signaling pathway
GO:0032355	response to estradiol
GO:0032870	cellular response to hormone stimulus
GO:0040014	regulation of multicellular organism growth
GO:0042593	glucose homeostasis
GO:0042755	eating behavior
GO:0045747	positive regulation of Notch signaling pathway
GO:0045820	negative regulation of glycolytic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048708	astrocyte differentiation
GO:0060019	radial glial cell differentiation
GO:0060396	growth hormone receptor signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070102	interleukin-6-mediated signaling pathway
GO:2001223	negative regulation of neuron migration

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013799 STAT transcription factor, protein interaction
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil

PFAM

PF00017
PF14633
PF02865
PF01017
PF02864

PRINTS

PR00401

PIRSF

SMART

SM00252
SM00964

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt