InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CUL2

Summary

InnateDB Protein

IDBP-69270.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CUL2

Protein Name

cullin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000363881

InnateDB Gene

IDBG-69264 (CUL2)

Protein Structure

UniProt Annotation

Function

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 487 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	487 [view]
Protein-Protein	485 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456	cellular response to hypoxia
GO:0097193	intrinsic apoptotic signaling pathway