InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CUL2

Summary

InnateDB Gene

IDBG-69264.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CUL2

Gene Name

cullin 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000108094

Encoded Proteins

IDBP-69266

cullin 2

IDBP-69268

cullin 2

IDBP-69270

cullin 2

IDBP-69272

cullin 2

IDBP-69274

cullin 2

IDBP-372990

cullin 2

IDBP-603588

cullin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:35008551-35090642

Strand

Reverse strand

Band

p11.21

Transcripts

ENST00000374751	ENSP00000363883
ENST00000374754	ENSP00000363886
ENST00000374749	ENSP00000363881
ENST00000374748	ENSP00000363880
ENST00000374746	ENSP00000363878
ENST00000421317	ENSP00000414095
ENST00000468804
ENST00000478044
ENST00000537177	ENSP00000444856

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 487 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	487 [view]
Protein-Protein	485 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0032403	protein complex binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0030163	protein catabolic process
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456	cellular response to hypoxia
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0030891	VCB complex
GO:0031461	cullin-RING ubiquitin ligase complex
GO:0031462	Cul2-RING ubiquitin ligase complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024231

View Gene Order

ENSBTAG00000007133

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_120916

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway

REACT_120956

Cellular responses to stress pathway

REACT_75774

Adaptive Immune System pathway

REACT_120815

Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway

REACT_6900

Immune System pathway

REACT_121311

Cellular response to hypoxia pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa05211

Renal cell carcinoma pathway

hsa04120

Ubiquitin mediated proteolysis pathway

hsa05200

Pathways in cancer pathway

INOH

PID NCI

hif1apathway

Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.607955 Hs.613492 Hs.82919

RefSeq

NM_001198777 NM_001198778 NM_001198779 NM_003591

HUGO

OMIM

CCDS

CCDS7179 CCDS73086

HPRD

06786

IMGT

EMBL

GenPept

RNA Seq Atlas