InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TJP2

Summary

InnateDB Protein

IDBP-69313.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TJP2

Protein Name

tight junction protein 2 (zona occludens 2)

Synonyms

C9DUPq21.11; DFNA51; DUP9q21.11; PFIC4; X104; ZO2;

Species

Homo sapiens

Ensembl Protein

ENSP00000345893

InnateDB Gene

IDBG-69307 (TJP2)

Protein Structure

UniProt Annotation

Function

Plays a role in tight junctions and adherens junctions.

Subcellular Localization

Cell junction, adherens junction. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Nucleus {ECO:0000250}. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. {ECO:0000250}.

Disease Associations

Familial hypercholanemia (FHCA) [MIM:607748]: A disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. {ECO:0000269PubMed:12704386}. Note=The disease may be caused by mutations affecting distinct genetic loci, including the gene represented in this entry.

Tissue Specificity

This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. {ECO:0000269PubMed:11018256}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004385	guanylate kinase activity
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0035329	hippo signaling
GO:0046939	nucleotide phosphorylation

Cellular Component

GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005912	adherens junction
GO:0005923	tight junction
GO:0030054	cell junction

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR001478 PDZ domain
IPR005417 Zona occludens protein
IPR005419 Zona occludens protein ZO-2
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00018
PF14604
PF00595
PF13180
PF00625
PF07653

PRINTS

PR00452
PR01597
PR01599

PIRSF

SMART

SM00326
SM00228
SM00072

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt