Version 5.4
Bos taurus Protein: GFAP
Summary
InnateDB Protein IDBP-693351.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GFAP
Protein Name Glial fibrillary acidic protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017997
InnateDB Gene IDBG-641035 (GFAP)
Protein Structure
UniProt Annotation
Function GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
Subcellular Localization Cytoplasm {ECO:0000250}. Note=Associated with intermediate filaments. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
Biological Process
GO:0010625 positive regulation of Schwann cell proliferation
GO:0010977 negative regulation of neuron projection development
GO:0014002 astrocyte development
GO:0030198 extracellular matrix organization
GO:0031102 neuron projection regeneration
GO:0045103 intermediate filament-based process
GO:0045109 intermediate filament organization
GO:0051580 regulation of neurotransmitter uptake
GO:0060020 Bergmann glial cell differentiation
GO:0060291 long-term synaptic potentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005882 intermediate filament
GO:0016020 membrane
GO:0042995 cell projection
GO:0044297 cell body
GO:0097449 astrocyte projection
Protein Structure and Domains
PDB ID
InterPro IPR001664 Intermediate filament protein
IPR006821 Intermediate filament head, DNA-binding domain
PFAM PF00038
PF04732
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q28115
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281189
UniGene Bt.21127
RefSeq NP_776490
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY174179 BC119892 L19867 Y08255
GenPept AAA51413 AAI19893 AAO18221 CAA69422

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca