Bos taurus Protein: SNCA
InnateDB Protein IDBP-693420.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNCA
Protein Name Alpha-synuclein
Species Bos taurus
Ensembl Protein ENSBTAP00000021300
InnateDB Gene IDBG-641103 (SNCA)
Protein Structure
UniProt Annotation
Function May be involved in the regulation of dopamine release and transport. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 259 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 259 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0019894 kinesin binding
GO:0030544 Hsp70 protein binding
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0043014 alpha-tubulin binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0045502 dynein binding
GO:0046872 metal ion binding
GO:0048156 tau protein binding
GO:0050544 arachidonic acid binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0001774 microglial cell activation
GO:0001921 positive regulation of receptor recycling
GO:0001956 positive regulation of neurotransmitter secretion
GO:0001963 synaptic transmission, dopaminergic
GO:0006631 fatty acid metabolic process
GO:0006638 neutral lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007006 mitochondrial membrane organization
GO:0007268 synaptic transmission
GO:0008344 adult locomotory behavior
GO:0010040 response to iron(II) ion
GO:0010517 regulation of phospholipase activity
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014048 regulation of glutamate secretion
GO:0014059 regulation of dopamine secretion
GO:0031115 negative regulation of microtubule polymerization
GO:0031623 receptor internalization
GO:0031648 protein destabilization
GO:0032026 response to magnesium ion
GO:0032410 negative regulation of transporter activity
GO:0032496 response to lipopolysaccharide
GO:0032769 negative regulation of monooxygenase activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034341 response to interferon-gamma
GO:0034599 cellular response to oxidative stress
GO:0035067 negative regulation of histone acetylation
GO:0040012 regulation of locomotion
GO:0042416 dopamine biosynthetic process
GO:0042417 dopamine metabolic process
GO:0042493 response to drug
GO:0042775 mitochondrial ATP synthesis coupled electron transport
GO:0043030 regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045807 positive regulation of endocytosis
GO:0045920 negative regulation of exocytosis
GO:0046928 regulation of neurotransmitter secretion
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048488 synaptic vesicle endocytosis
GO:0048489 synaptic vesicle transport
GO:0050806 positive regulation of synaptic transmission
GO:0050808 synapse organization
GO:0050812 regulation of acyl-CoA biosynthetic process
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051585 negative regulation of dopamine uptake involved in synaptic transmission
GO:0051612 negative regulation of serotonin uptake
GO:0051622 negative regulation of norepinephrine uptake
GO:0055114 oxidation-reduction process
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060291 long-term synaptic potentiation
GO:0060732 positive regulation of inositol phosphate biosynthetic process
GO:0061024 membrane organization
GO:0070495 negative regulation of thrombin receptor signaling pathway
GO:0070555 response to interleukin-1
GO:0071280 cellular response to copper ion
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:1901214 regulation of neuron death
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0015629 actin cytoskeleton
GO:0016234 inclusion body
GO:0030424 axon
GO:0030426 growth cone
GO:0031092 platelet alpha granule membrane
GO:0043205 fibril
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
InterPro IPR001058 Synuclein
IPR002460 Alpha-synuclein
IPR002462 Gamma-synuclein
PFAM PF01387
Post-translational Modifications
SwissProt Q3T0G8
PhosphoSite PhosphoSite-
UniProt Splice Variant
Entrez Gene 282857
UniGene Bt.12770
RefSeq NP_001029213
EMBL BC102402 BC149585
GenPept AAI02403 AAI49586