Bos taurus Gene: SNCA
Summary
InnateDB Gene IDBG-641103.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNCA
Gene Name Alpha-synuclein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000024957
Encoded Proteins
Alpha-synuclein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] SNCA acts as a danger-associated molecular pattern that activates the expression of TLRs to initiate the proinflammatory pathway and microglial activation.
[Mus musculus] Snca acts as a danger-associated molecular pattern that activates the expression of TLRs to initiate the proinflammatory pathway and microglial activation. (Demonstrated in human)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145335:
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer\'s disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:36285494-36432426
Strand Forward strand
Band
Transcripts
ENSBTAT00000021300 ENSBTAP00000021300
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 259 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 259 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0019894 kinesin binding
GO:0030544 Hsp70 protein binding
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0043014 alpha-tubulin binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0045502 dynein binding
GO:0046872 metal ion binding
GO:0048156 tau protein binding
GO:0050544 arachidonic acid binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0001774 microglial cell activation
GO:0001921 positive regulation of receptor recycling
GO:0001956 positive regulation of neurotransmitter secretion
GO:0001963 synaptic transmission, dopaminergic
GO:0006631 fatty acid metabolic process
GO:0006638 neutral lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007006 mitochondrial membrane organization
GO:0007268 synaptic transmission
GO:0008344 adult locomotory behavior
GO:0010040 response to iron(II) ion
GO:0010517 regulation of phospholipase activity
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014048 regulation of glutamate secretion
GO:0014059 regulation of dopamine secretion
GO:0031115 negative regulation of microtubule polymerization
GO:0031623 receptor internalization
GO:0031648 protein destabilization
GO:0032026 response to magnesium ion
GO:0032410 negative regulation of transporter activity
GO:0032496 response to lipopolysaccharide
GO:0032769 negative regulation of monooxygenase activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034341 response to interferon-gamma
GO:0034599 cellular response to oxidative stress
GO:0035067 negative regulation of histone acetylation
GO:0040012 regulation of locomotion
GO:0042416 dopamine biosynthetic process
GO:0042417 dopamine metabolic process
GO:0042493 response to drug
GO:0042775 mitochondrial ATP synthesis coupled electron transport
GO:0043030 regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045807 positive regulation of endocytosis
GO:0045920 negative regulation of exocytosis
GO:0046928 regulation of neurotransmitter secretion
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048488 synaptic vesicle endocytosis
GO:0048489 synaptic vesicle transport
GO:0050806 positive regulation of synaptic transmission
GO:0050808 synapse organization
GO:0050812 regulation of acyl-CoA biosynthetic process
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051585 negative regulation of dopamine uptake involved in synaptic transmission
GO:0051612 negative regulation of serotonin uptake
GO:0051622 negative regulation of norepinephrine uptake
GO:0055114 oxidation-reduction process
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0060291 long-term synaptic potentiation
GO:0060732 positive regulation of inositol phosphate biosynthetic process
GO:0061024 membrane organization
GO:0070495 negative regulation of thrombin receptor signaling pathway
GO:0070555 response to interleukin-1
GO:0071280 cellular response to copper ion
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:1901214 regulation of neuron death
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0015629 actin cytoskeleton
GO:0016234 inclusion body
GO:0030424 axon
GO:0030426 growth cone
GO:0031092 platelet alpha granule membrane
GO:0043205 fibril
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Amyloids pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
Amyloids pathway
Disease pathway
Disease pathway
Amyloids pathway
KEGG
Alzheimer's disease pathway
Parkinson's disease pathway
Alzheimer's disease pathway
Parkinson's disease pathway
INOH
PID BIOCARTA
Alpha-synuclein and parkin-mediated proteolysis in parkinson`s disease [Biocarta view]
PID NCI
Alpha-synuclein signaling
Cross-References
SwissProt Q3T0G8
TrEMBL A6QQ08
UniProt Splice Variant
Entrez Gene 282857
UniGene Bt.12770
RefSeq NM_001034041 XM_005207754 XM_005207755 XM_005207756 XM_005207757 XM_005207758
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102402 BC149585
GenPept AAI02403 AAI49586
RNA Seq Atlas 282857
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

(Move your mouse over the image to view a more detailed version)