InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SNCA

Summary

InnateDB Gene

IDBG-641103.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNCA

Gene Name

Alpha-synuclein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000024957

Encoded Proteins

IDBP-693420

Alpha-synuclein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21747756

[Homo sapiens] SNCA acts as a danger-associated molecular pattern that activates the expression of TLRs to initiate the proinflammatory pathway and microglial activation.

PMID 21747756

[Mus musculus] Snca acts as a danger-associated molecular pattern that activates the expression of TLRs to initiate the proinflammatory pathway and microglial activation. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145335:
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer\'s disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:36285494-36432426

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021300

ENSBTAP00000021300

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 259 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	259 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0005507	copper ion binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008198	ferrous iron binding
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0019894	kinesin binding
GO:0030544	Hsp70 protein binding
GO:0042393	histone binding
GO:0042802	identical protein binding
GO:0043014	alpha-tubulin binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0045502	dynein binding
GO:0046872	metal ion binding
GO:0048156	tau protein binding
GO:0050544	arachidonic acid binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0001774	microglial cell activation
GO:0001921	positive regulation of receptor recycling
GO:0001956	positive regulation of neurotransmitter secretion
GO:0001963	synaptic transmission, dopaminergic
GO:0006631	fatty acid metabolic process
GO:0006638	neutral lipid metabolic process
GO:0006644	phospholipid metabolic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007006	mitochondrial membrane organization
GO:0007268	synaptic transmission
GO:0008344	adult locomotory behavior
GO:0010040	response to iron(II) ion
GO:0010517	regulation of phospholipase activity
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0014048	regulation of glutamate secretion
GO:0014059	regulation of dopamine secretion
GO:0031115	negative regulation of microtubule polymerization
GO:0031623	receptor internalization
GO:0031648	protein destabilization
GO:0032026	response to magnesium ion
GO:0032410	negative regulation of transporter activity
GO:0032496	response to lipopolysaccharide
GO:0032769	negative regulation of monooxygenase activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034341	response to interferon-gamma
GO:0034599	cellular response to oxidative stress
GO:0035067	negative regulation of histone acetylation
GO:0040012	regulation of locomotion
GO:0042416	dopamine biosynthetic process
GO:0042417	dopamine metabolic process
GO:0042493	response to drug
GO:0042775	mitochondrial ATP synthesis coupled electron transport
GO:0043030	regulation of macrophage activation
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045807	positive regulation of endocytosis
GO:0045920	negative regulation of exocytosis
GO:0046928	regulation of neurotransmitter secretion
GO:0048168	regulation of neuronal synaptic plasticity
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048488	synaptic vesicle endocytosis
GO:0048489	synaptic vesicle transport
GO:0050806	positive regulation of synaptic transmission
GO:0050808	synapse organization
GO:0050812	regulation of acyl-CoA biosynthetic process
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051585	negative regulation of dopamine uptake involved in synaptic transmission
GO:0051612	negative regulation of serotonin uptake
GO:0051622	negative regulation of norepinephrine uptake
GO:0055114	oxidation-reduction process
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0060291	long-term synaptic potentiation
GO:0060732	positive regulation of inositol phosphate biosynthetic process
GO:0061024	membrane organization
GO:0070495	negative regulation of thrombin receptor signaling pathway
GO:0070555	response to interleukin-1
GO:0071280	cellular response to copper ion
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:1901214	regulation of neuron death

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0015629	actin cytoskeleton
GO:0016234	inclusion body
GO:0030424	axon
GO:0030426	growth cone
GO:0031092	platelet alpha granule membrane
GO:0043205	fibril
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm