Bos taurus Protein: ABCG2 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-693507.2 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | ABCG2 | ||||||||||||||
Protein Name | ATP-binding cassette sub-family G member 2 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Protein | ENSBTAP00000051068 | ||||||||||||||
InnateDB Gene | IDBG-641167 (ABCG2) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain (By similarity). {ECO:0000250}. | ||||||||||||||
Subcellular Localization | Cell membrane; Multi-pass membrane protein. Mitochondrion membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | |||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | |||||||||||||||
InterPro |
IPR003439
ABC transporter-like IPR003593 AAA+ ATPase domain IPR013525 ABC-2 type transporter IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00005
PF01061 |
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PRINTS | |||||||||||||||
PIRSF | |||||||||||||||
SMART |
SM00382
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q4GZT4 | ||||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||||
TrEMBL | I6LHT2 | ||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 536203 | ||||||||||||||
UniGene | Bt.51973 | ||||||||||||||
RefSeq | XP_005207852 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AJ871176 DAAA02017016 DQ825760 EU570105 JN808308 JQ398801 | ||||||||||||||
GenPept | ABI20144 ACB47220 AFA52821 AFH35510 CAI38796 | ||||||||||||||