InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ABCG2

Summary

InnateDB Gene

IDBG-641167.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCG2

Gene Name

ATP-binding cassette sub-family G member 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017704

Encoded Proteins

IDBP-693507

ATP-binding cassette sub-family G member 2

IDBP-693509

ATP-binding cassette sub-family G member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118777:
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:37913110-38030583

Strand

Forward strand

Band

Transcripts

ENSBTAT00000055044	ENSBTAP00000051068
ENSBTAT00000023552	ENSBTAP00000023552

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042803	protein homodimerization activity